HPV-18 E6*I modulates HPV-18 full-length E6 functions in a cell cycle dependent manner

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PDZRN3/LNX3 is a novel target of human papillomavirus type 16 (HPV-16) and HPV-18 E6.

High-risk human papillomavirus (HPV) E6 proteins have a C-terminal PDZ binding motif through which they bind, and target for proteasome-mediated degradation, a number of PDZ-containing cellular targets. Recent studies have suggested that the RING-containing ubiquitin-protein ligase PDZRN3 might also be an HPV E6 target. In this analysis, we show that HPV-16 and HPV-18 E6 can target PDZRN3 in a ...

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ژورنال

عنوان ژورنال: International Journal of Cancer

سال: 2004

ISSN: 0020-7136,1097-0215

DOI: 10.1002/ijc.20184